A fast and validated mass spectrometry method for the evaluation of human serum albumin structural modifications in the clinical field.

@article{Naldi2013AFA,
  title={A fast and validated mass spectrometry method for the evaluation of human serum albumin structural modifications in the clinical field.},
  author={Marina Naldi and Ferdinando Antonino Giannone and Maurizio Baldassarre and Marco Domenicali and Paolo Caraceni and Mauro Bernardi and Carlo Bertucci},
  journal={European journal of mass spectrometry},
  year={2013},
  volume={19 6},
  pages={
          491-6
        }
}
A relatively fast analytical method for the identification and quantification of the post-transcriptional changes (PTCs) occurring in circulating human serum albumin (HSA) was developed. HSA is the most abundant protein in plasma and it represents the main determinant of plasma oncotic pressure, thus being the main modulator of fluid distribution between body compartments. Cirrhotic patients have low levels of HSA. Moreover, recent studies have demonstrated that during liver cirrhosis HSA… CONTINUE READING
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