A fast and efficient gene-network reconstruction method from multiple over-expression experiments

@inproceedings{Stokic2009AFA,
  title={A fast and efficient gene-network reconstruction method from multiple over-expression experiments},
  author={Dejan Stokic and Rudolf Hanel and Stefan Thurner},
  booktitle={BMC Bioinformatics},
  year={2009}
}
Reverse engineering of gene regulatory networks presents one of the big challenges in systems biology. Gene regulatory networks are usually inferred from a set of single-gene over-expressions and/or knockout experiments. Functional relationships between genes are retrieved either from the steady state gene expressions or from respective time series. We present a novel algorithm for gene network reconstruction on the basis of steady-state gene-chip data from over-expression experiments. The… CONTINUE READING
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