A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis.

@article{Barrington1998AFI,
  title={A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis.},
  author={R E Barrington and Mark A. Subler and Elaine Rands and Charles A. Omer and Patricia J. Miller and Jeff E. Hundley and Steven K. Koester and Dean A. Troyer and David J. Bearss and Michael W. Conner and Jackson B. Gibbs and Kelly Hamilton and Kenneth S. Koblan and Scott D. Mosser and Thomas J. O'Neill and Michael D. Schaber and Edith T. Senderak and Jolene J. Windle and Allen Oliff and Nancy E. Kohl},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 1},
  pages={85-92}
}
The farnesyltransferase inhibitor L-744,832 selectively blocks the transformed phenotype of cultured cells expressing a mutated H-ras gene and induces dramatic regression of mammary and salivary carcinomas in mouse mammary tumor virus (MMTV)-v-Ha-ras transgenic mice. To better understand how the farnesyltransferase inhibitors might be used in the treatment of human tumors, we have further explored the mechanisms by which L-744,832 induces tumor regression in a variety of transgenic mouse tumor… CONTINUE READING

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