A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin.

@article{Steiner1985AFS,
  title={A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin.},
  author={Ernie Steiner and Lennart Iselius and Gunnar Alv{\'a}n and Jan E. Lindsten and Folke Sj{\"o}qvist},
  journal={Clinical pharmacology and therapeutics},
  year={1985},
  volume={38 4},
  pages={394-401}
}
Debrisoquin hydroxylation capacity determined as the ratio of debrisoquin to 4-OH-debrisoquin (DMR) in urine after a single oral dose (10 mg) was studied in 52 nuclear families comprising 226 subjects. The relative importance of genetic and environmental factors for DMR was studied by path analysis. There was a significant negative correlation between DMR and coffee intake but no significant correlations between DMR and sex, age, alcohol intake, or smoking habits. Path analysis showed that… CONTINUE READING

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