A family portrait of the RIO kinases.

  title={A family portrait of the RIO kinases.},
  author={Nicole A. LaRonde-LeBlanc and Alexander Wlodawer},
  journal={The Journal of biological chemistry},
  volume={280 45},
The RIO family of atypical serine protein kinases has been first characterized only recently. It consists of enzymes that contain a unique domain with a characteristic kinase sequence motif and usually some additional domains. At least two RIO proteins, Rio1 and Rio2, are present in organisms varying from Archaea to humans, with a third Rio3 subfamily present only in multicellular eukaryotes. Yeast Rio1 and Rio2 proteins have been implicated in the processing of 20 S pre-rRNA and are necessary… CONTINUE READING