A family of proteins related to Spätzle, the toll receptor ligand, are encoded in the Drosophila genome.

@article{Parker2001AFO,
  title={A family of proteins related to Sp{\"a}tzle, the toll receptor ligand, are encoded in the Drosophila genome.},
  author={John S. Parker and Kenji Mizuguchi and Nicholas J Gay},
  journal={Proteins},
  year={2001},
  volume={45 1},
  pages={71-80}
}
The Drosophila gene Spätzle encodes the activating ligand for the Toll receptor. This signaling pathway is required for dorso-ventral patterning in the early embryo and an antifungal immune response in larvae and adults. The genome sequence of Drosophila shows that there are a total of eight Toll-like receptors and these may function in other aspects of embryonic development and innate immunity. Here we describe five Drosophila homologues of Spätzle (Spz2-6) found using an iterative searching… CONTINUE READING

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