A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.

@article{Rooij2009AFO,
  title={A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.},
  author={Eva van Rooij and Daniel Quiat and Brett Andrew Johnson and Lillian B. Sutherland and Xiaoxia Qi and J. A. Richardson and Robert J Kelm and Eric N Olson},
  journal={Developmental cell},
  year={2009},
  volume={17 5},
  pages={662-73}
}
Myosin is the primary regulator of muscle strength and contractility. Here we show that three myosin genes, Myh6, Myh7, and Myh7b, encode related intronic microRNAs (miRNAs), which, in turn, control muscle myosin content, myofiber identity, and muscle performance. Within the adult heart, the Myh6 gene, encoding a fast myosin, coexpresses miR-208a, which regulates the expression of two slow myosins and their intronic miRNAs, Myh7/miR-208b and Myh7b/miR-499, respectively. miR-208b and miR-499… CONTINUE READING