A family of mammalian Na+-dependent L-ascorbic acid transporters

@article{Tsukaguchi1999AFO,
  title={A family of mammalian Na+-dependent L-ascorbic acid transporters},
  author={Hiroyasu Tsukaguchi and Taro Tokui and Bryan Mackenzie and Urs V. Berger and Xing‐Zhen Chen and Yangxi Wang and Richard F. Brubaker and Matthias A. Hediger},
  journal={Nature},
  year={1999},
  volume={399},
  pages={70-75}
}
Vitamin C (L-ascorbic acid) is essential for many enzymatic reactions, in which it serves to maintain prosthetic metal ions in their reduced forms (for example, Fe2+, Cu+),, and for scavenging free radicals in order to protect tissues from oxidative damage. The facilitative sugar transporters of the GLUT type can transport the oxidized form of the vitamin, dehydroascorbic acid, but these transporters are unlikely to allow significant physiological amounts of vitamin C to be taken up in the… Expand
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TLDR
The main focus of this review is on the SLC23 family of ascorbic acid transporters,Transporters of DHA and nucleobases are also briefly discussed for completeness. Expand
Vitamin C transporters
TLDR
In humans, the maintenance of a low daily requirement of vitamin C is attained through an efficient system for the recycling of the vitamin involving the two families of vitaminC transporters. Expand
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TLDR
A general effect in which ascorbic acid functions like a glucose/monocarboxylate uptake switch in tissues expressing ascorBic acid transporters is described. Expand
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TLDR
The various pathways of regeneration of ascorbate and their relative contributions to the avoidance of vitamin loss in plasma or cell culture medium are discussed. Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid
TLDR
Observations indicate that mammalian facilitative hexose transporters are a physiologically significant pathway for the uptake and accumulation of vitamin C by cells, and suggest a mechanism for the accumulation of ascorbic acid against a concentration gradient. Expand
Requirement for Na(+)-dependent ascorbic acid transport in osteoblast function.
TLDR
Na(+)-dependent ascorbic acid transport is required for MC3T3-E1 cells to achieve the millimolar intracellular vitamin C concentrations necessary for maximal prolyl hydroxylase activity and expression of the osteoblast phenotype. Expand
Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters.
TLDR
The transport of dehydroascorbic acid by GLUT1 is defined as a mechanism by which the brain acquires vitamin C, and the oxidation of ascorbic acid is pointed to as a potentially important regulatory step in accumulation of the vitamin by the brain. Expand
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
TLDR
A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+. Expand
Characterization of ascorbic acid uptake by isolated rat kidney cells.
TLDR
Findings indicated that ascorbic acid is reabsorbed by the kidney in a sodium-dependent active transport process that is not common to other acid anions and has some specificity for the ascorBic acid structure. Expand
Vitamin C: newer insights into its biochemical functions.
  • H. Padh
  • Chemistry, Medicine
  • Nutrition reviews
  • 1991
TLDR
It is apparent that ascorbic acid does not directly participate in enzyme-catalyzed conversion of substrate to product, but the vitamin regenerates prosthetic metal ions in these enzymes in their required reduced forms, in agreement with other antioxidant functions of vitamin C, e.g., scavenging of free radicals. Expand
Biology of free radical scavengers: an evaluation of ascorbate
  • R. C. Rose, A. Bode
  • Chemistry, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1993
TLDR
Ascorbic acid is discussed in detail, and an analysis is made of whether it has the properties mentioned, and several water‐soluble candidates are mentioned, with most having no more than one or two of the attributes listed. Expand
Ocular ascorbate transport and metabolism.
  • R. C. Rose, A. Bode
  • Chemistry, Medicine
  • Comparative biochemistry and physiology. A, Comparative physiology
  • 1991
TLDR
Ascorbic acid is present at a high concentration in various ocular compartments of diurnal animals, regardless of whether the animal synthesizes the compound or extracts it from the diet. Expand
Glucose Transporter Isoforms GLUT1 and GLUT3 Transport Dehydroascorbic Acid*
TLDR
GLUT1 and GLUT3 isoforms are the specific glucose transporter isoforms which mediate DHA transport and subsequent accumulation of AA according to Xenopus laevis oocyte expression system studies. Expand
Electrogenic Na+-ascorbate cotransport in cultured bovine pigmented ciliary epithelial cells.
The high level of ascorbic acid (AA) in the aqueous humor of many mammals suggests an active transport of AA across the double-layered ciliary epithelium from blood to aqueous humor. We used [14C]AAExpand
...
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3
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