A family of ligands for the TNF receptor superfamily.

  title={A family of ligands for the TNF receptor superfamily.},
  author={David Cosman},
  journal={Stem cells},
  volume={12 5},
Recent progress in the definition of molecules involved in immune regulation has led to the discovery of a number of type I membrane glycoproteins with a distinctive, cysteine-rich, repetitive domain structure within their extracellular regions. Because the prototype members of this family are receptors for cytokines (tumor necrosis factor [TNF] and nerve growth factor [NGF]), it was expected that the ligands for the other receptors would possess cytokine-like activities. This prediction has… CONTINUE READING


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