A family of interferon-induced Mx-related mRNAs encodes cytoplasmic and nuclear proteins in rat cells.

@article{Meier1988AFO,
  title={A family of interferon-induced Mx-related mRNAs encodes cytoplasmic and nuclear proteins in rat cells.},
  author={Evelyn Meier and J{\"u}rg F{\"a}h and Marianne Grob and R End and Peter Staeheli and Otto Haller},
  journal={Journal of virology},
  year={1988},
  volume={62 7},
  pages={2386-93}
}
Mouse Mx protein, an interferon (IFN)-induced nuclear protein, confers selective resistance to influenza virus. We show here that, as with influenza virus-resistant Mx+ mouse embryo cells, influenza virus mRNA accumulation and protein synthesis are strongly inhibited in rat embryo cells treated with IFN-alpha/beta. IFN-alpha/beta induced in rat cells the synthesis of Mx-related mRNAs migrating on Northern (RNA) gels as two bands of about 3.5 and 2.5 kilobases which directed the synthesis of… CONTINUE READING

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