A family of human receptors structurally related to Drosophila Toll.

@article{Rock1998AFO,
  title={A family of human receptors structurally related to Drosophila Toll.},
  author={Fernando L. Rock and G. Hardiman and Jackie C. Timans and Robert A. Kastelein and J Fernando Bazan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 2},
  pages={
          588-93
        }
}
  • F. Rock, G. Hardiman, +2 authors J. Bazan
  • Published 1998
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
The discovery of sequence homology between the cytoplasmic domains of Drosophila Toll and human interleukin 1 receptors has sown the conviction that both molecules trigger related signaling pathways tied to the nuclear translocation of Rel-type transcription factors. This conserved signaling scheme governs an evolutionarily ancient immune response in both insects and vertebrates. We report the molecular cloning of a class of putative human receptors with a protein architecture that is similar… Expand
Activation of insect and vertebrate toll signaling: from endogenous cytokine ligand to direct recognition of pathogen patterns.
TLDR
The Toll receptor families from insects and vertebrates have structural and evolutionary relationships and it was considered likely that they fulfilled similar functions in their respective organisms, but it has become clear that the way in which they recognise pathogens in Drosophila and mammals is quite distinct. Expand
TLR6: A novel member of an expanding toll-like receptor family.
TLDR
The molecular cloning and characterization of a new member of Toll-like receptor family, Toll- like receptor 6 (TLR6) is reported, suggesting that TLR6 is a novel member of an expanding TLR family. Expand
The Biology of Toll-Like Receptors in Mice
TLDR
Toll was originally identified as a molecule essential for determining dorsoventral polarity in the development of drosophila melanogaster, and a family of Toll-like receptors, named Toll- like receptors (TLRs), was discovered via a database search. Expand
Molecular Cloning and Functional Characterization of Chicken Toll-like Receptors
TLDR
Results indicated that chTLR type 2 covers two major microbe patterns, lipoproteins and LPS, which are regulated by TLR2 and TLR4 in mammals. Expand
A family of proteins related to Spätzle, the toll receptor ligand, are encoded in the Drosophila genome
TLDR
Five Drosophila homologues of Spätzle (Spz2‐6) found using an iterative searching method are described, providing evidence that the family arose by ancient gene duplication events and indicates that the gene products may represent activating ligands for corresponding Toll receptors. Expand
Toll-like receptors: a family of pattern-recognition receptors in mammals
TLDR
TLR-specific signaling pathways and cellular responses function as sentinels of the mammalian immune system that can discriminate between diverse pathogen-associated molecular patterns and then elicit pathogenic-specific cellular immune responses. Expand
The biology of Toll-like receptors.
TLDR
Mammalian TLR proteins appear to represent a conserved family of innate immune recognition receptors, coupled to a signaling pathway that is conserved in mammals, insects, and plants, resulting in the activation of genes that mediate innate immune defenses. Expand
Toll receptors: an expanding role in our understanding of human disease
TLDR
Toll receptor proteins in Drosophila are involved in establishing the dorsal‐ventral axis in embryogenesis as well as participating in the innate immune response to invading pathogens, and a better understanding of this response may provide improved therapeutic modalities in the treatment of bacterial and fungal sepsis. Expand
Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice.
TLDR
The cloning and characterization of the mouse homologue of human TLR5 is described and it is shown that Tlr5 is expressed predominantly in liver and lung with low-level expression in most other tissues examined, suggesting that, as with other members of this family, TLR5 may play a role in host response to bacterial gram-negative infections. Expand
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.
TLDR
The cloning of two novel human genes, TIL3 and TIL4 (Toll/IL-1R-like-3, -4) that exhibit homology to both the leucine-rich repeat extracellular domains and the IL-1 R-like intracellular domains of human and Drosophila Toll are reported. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 54 REFERENCES
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TLDR
The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila. Expand
A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled(*)
TLDR
Observations predict the existence of a family of signal transduction pathways that are homologous to the pathway that determines tissue polarity in Drosophila. Expand
A conserved signaling pathway: the Drosophila toll-dorsal pathway.
The Toll-Dorsal pathway in Drosophila and the interleukin-1 receptor (IL-1R)-NF-kappa B pathway in mammals are homologous signal transduction pathways that mediate several different biologicalExpand
Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila
TLDR
The isolation and characterization of a novel gene, tlr (for Toll-like receptor), which encodes a protein containing multiple LRRs in its presumed extracellular domain, a single transmembrane segment and homology to the cytoplasmic domain of the interleukin 1 receptor in its presumption intracellular domain are reported. Expand
A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B.
  • S. Wasserman
  • Biology, Medicine
  • Molecular biology of the cell
  • 1993
TLDR
The establishment of dorsoventral polarity in the Drosophila embryo and its relationship to a mammalian signal transduction pathway is considered. Expand
T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family (*)
TLDR
Comparisons between new proteins that share homology with the signaling domain of the type I interleukin-1 receptor and known IL-1RI homologous proteins revealed six clusters of amino acid similarity, indicating that the sequence homology between IL- 1RI and T1/ST2 indicates a functional homology as well. Expand
Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal.
TLDR
A model is proposed in which pll receives a signal from activated Toll and phosphorylates tube, which then participates directly in dl activation, which results in a striking synergistic activation of dl. Expand
Ventralization of the Drosophila embryo by deletion of extracellular leucine-rich repeats in the Toll protein.
TLDR
The view that Toll is a receptor whose extracellular domain regulates the intrinsic signaling activity of its cytoplasmic domain is supported. Expand
Signals from the IL-1 receptor homolog, Toll, can activate an immune response in a Drosophila hemocyte cell line.
TLDR
The endogenous Toll gene is expressed in mbn-2 cells, indicating that this gene may normally play a role in Drosophila blood cells, and Toll10B was found to increase CecA1 transcription, as detected with a cotransfected CecA 1-lacZ reporter gene construct. Expand
Molecular characterization and modular analysis of human MyD88.
TLDR
The MyD88 protein has a modular structure composed of an N-terminal 'death domain' (DD) similar to the intracellular segments of TNF receptor 1 (TNFR1) and FAS and a C- terminal region related to the signaling domains of vertebrate interleukin-1 receptors (IL-1R) and the Drosophila morphogen Toll. Expand
...
1
2
3
4
5
...