A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

@article{Bolger1993AFO,
  title={A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.},
  author={G. Bolger and T. Michaeli and T. Martins and T. St. John and B. Steiner and L. Rodgers and M. Riggs and M. Wigler and K. Ferguson},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 10},
  pages={
          6558-71
        }
}
  • G. Bolger, T. Michaeli, +6 authors K. Ferguson
  • Published 1993
  • Biology, Medicine
  • Molecular and cellular biology
  • We have isolated cDNAs for four human genes (DPDE1 through DPDE4) closely related to the dnc learning and memory locus of Drosophila melanogaster. The deduced amino acid sequences of the Drosophila and human proteins have considerable homology, extending beyond the putative catalytic region to include two novel, highly conserved, upstream conserved regions (UCR1 and UCR2). The upstream conserved regions are located in the amino-terminal regions of the proteins and appear to be unique to these… CONTINUE READING
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