A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

@article{Obrien2003AFO,
  title={A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.},
  author={Julie A O'brien and Wei Lemaire and Tsing-bau Chen and Raymond S. L. Chang and Marlene A. Jacobson and Sookhee N. Ha and Craig W. Lindsley and Herv{\'e} J. Schaffhauser and Cyrille Sur and Douglas J. Pettibone and P. Jeffrey Conn and David Williams},
  journal={Molecular pharmacology},
  year={2003},
  volume={64 3},
  pages={
          731-40
        }
}
We have identified a family of highly selective allosteric modulators of the group I metabotropic glutamate receptor subtype 5 (mGluR5). This family of closely related analogs exerts a spectrum of effects, ranging from positive to negative allosteric modulation, and includes compounds that do not themselves modulate mGluR5 agonist activity but rather prevent other family members from exerting their modulatory effects. 3,3'-Difluorobenzaldazine (DFB) has no agonist activity, but it acts as a… 
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