A family of heptahelical receptors with adhesion-like domains: a marriage between two super families.

@article{Hayflick2000AFO,
  title={A family of heptahelical receptors with adhesion-like domains: a marriage between two super families.},
  author={Joel S. Hayflick},
  journal={Journal of receptor and signal transduction research},
  year={2000},
  volume={20 2-3},
  pages={119-31}
}
  • Joel S. Hayflick
  • Published 2000 in
    Journal of receptor and signal transduction…
Some G protein-coupled receptors (GPCRs) are regulators of cell adhesion via inside-out effector signaling pathways. Such is the case with leukocyte chemokine receptors which stimulate intracellular second messenger pathways resulting in upregulation of integrin adhesion to ligands present in the extracellular matrix or on opposing cells resulting in chemotaxis and extravasation during immune surveillance. Remarkably, a family of GPCRs has recently been discovered that may themselves be… CONTINUE READING

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