A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata.

Abstract

Candida glabrata is a yeast pathogen of humans. We have established a tissue culture model to analyze the interaction of C. glabrata with macrophages. Transcript profiling of yeast ingested by macrophages reveals global changes in metabolism as well as increased expression of a gene family (YPS genes) encoding extracellular glycosylphosphatidylinositol… (More)

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