A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase.

@article{Measday1997AFO,
  title={A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase.},
  author={Vivien Measday and Lynda Moore and Ravi Retnakaran and Junho Lee and M. S Donoviel and Aaron M Neiman and Brenda Andrews},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 3},
  pages={1212-23}
}
In budding yeast, entry into the mitotic cell cycle, or Start, requires the Cdc28 cyclin-dependent kinase (Cdk) and one of its three associated G1 cyclins, Cln1, Cln2, or Cln3. In addition, two other G1 cyclins, Pcl1 and Pcl2, associate with a second Cdk, Pho85, to contribute to Start. Although Pho85 is not essential for viability, Pcl1,2-Pho85 kinase complexes become essential for Start in the absence of Cln1,2-Cdc28 kinases. In addition, Pho85 interacts with a third cyclin, Pho80, to regulate… CONTINUE READING
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