A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins.

@article{Bach1997AFO,
  title={A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins.},
  author={Ingolf Bach and Catherine Carri{\`e}re and Heather P. Ostendorff and Bogi Andersen and Michael G. Rosenfeld},
  journal={Genes & development},
  year={1997},
  volume={11 11},
  pages={1370-80}
}
The essential roles of LIM homeodomain proteins in cell fate determination during development have been demonstrated in organisms as divergent as Drosophila and higher mammals. We have isolated murine cDNAs encoding two highly homologous proteins that specifically interact with the LIM domains of P-Lim/Lhx3 and several other LIM homeodomain factors. Transcripts encoding these factors can be detected as early as mouse E8.5, with maximal expression observed in regions of the embryo in which the… CONTINUE READING
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