A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking.

@article{Nielsen2001AFO,
  title={A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking.},
  author={Finn Cilius Nielsen and J. Nielsen and Jan Christiansen},
  journal={Scandinavian journal of clinical and laboratory investigation. Supplementum},
  year={2001},
  volume={234},
  pages={93-9}
}
During a search for trans-acting factors associating with insulin-like growth factor II (IGF-II) mRNAs, we recently identified a family of three IGF-II mRNA-binding Proteins (IMP1, IMP2 and IMP3) that exhibit multiple attachments to IGF-II leader 3 mRNA and the reciprocally imprinted H19 RNA. IMPs contain the unique combination of two RNA recognition motifs (RRMs) and four hnRNP K homology (KH) domains. IMP1 is orthologous to the chicken zipcode-binding protein (ZBP-1), and the mouse c-myc… CONTINUE READING

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