A family of Acrp30/adiponectin structural and functional paralogs.

  title={A family of Acrp30/adiponectin structural and functional paralogs.},
  author={G. William Wong and Jin Gene Wang and Christopher Hug and Tsu-Shuen Tsao and Harvey F. Lodish},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 28},
Biochemical, genetic, and animal studies in recent years have established a critical role for the adipokine Acrp30/adiponectin in controlling whole-body metabolism, particularly by enhancing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. We describe a widely expressed and highly conserved family of adiponectin paralogs designated as C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. In the present study, we focus on mCTRP2, the mouse… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS