A familiarity signal in human anterior medial temporal cortex?

@article{Henson2003AFS,
  title={A familiarity signal in human anterior medial temporal cortex?},
  author={Richard N. A. Henson and Selene Cansino and Jane E. Herron and William G. K. Robb and Michael D. Rugg},
  journal={Hippocampus},
  year={2003},
  volume={13}
}
The medial temporal lobe (MTL) comprises the hippocampal complex and amygdala, along with distinct cortical regions, including the parahippocampal, entorhinal, and perirhinal cortices. It has been suggested that different components of the MTL support dissociable memory functions (see, e.g., Eichenbaum et al., 1994). Of particular relevance to the present report is evidence from lesion studies in nonhuman primates suggesting that the perirhinal region plays a key role in visual recognition… 
Multiple signals of recognition memory in the medial temporal lobe
The medial temporal lobe (MTL) is known to play an essential role in recognition memory (the ability to judge the prior occurrence of a stimulus). Electrophysiological studies in nonhuman primates
The medial temporal lobe.
TLDR
This analysis draws on studies of human memory impairment and animal models of memory impairment, as well as neurophysiological and neuroimaging data, to show that this system is principally concerned with memory and operates with neocortex to establish and maintain long-term memory.
Dissociable contributions within the medial temporal lobe to encoding of object-location associations.
TLDR
The bilateral posterior posterior PHC is found to participate in encoding of both the object associated with a location and the location associated with an object, which is in contrast to previous work which found that activity in an area in the left anterior PHC and the right anterior MTL was only correlated with the memory for the location related to an object.
The medial temporal lobe and recognition memory.
TLDR
Evidence from neuropsychological, neuroimaging, and neurophysiological studies of humans, monkeys, and rats indicates that different subregions of the MTL make distinct contributions to recollection and familiarity; the data suggest that the hippocampus is critical for recollection but not familiarity.
Human Hippocampal and Parahippocampal Activity during Visual Associative Recognition Memory for Spatial and Nonspatial Stimulus Configurations
TLDR
To better understand the division of function between HF and PHR during recognition memory in humans, activity of both areas in healthy young adults during an associative recognition memory task is measured using functional magnetic resonance imaging.
Specialization in the medial temporal lobe for processing of objects and scenes
TLDR
Oddity tasks administered to amnesic patients with either selective hippocampal damage or more extensive medial temporal damage provide compelling evidence that the human hippocampus and perirhinal cortex are critical to processes beyond long‐term declarative memory and may subserve spatial and object perception, respectively.
Distributed category‐specific recognition‐memory signals in human perirhinal cortex
TLDR
These findings provide support for proposals, recently raised in the neurophysiological literature, that the prior occurrence of objects is coded by distributed PrC representations and suggest that the stimulus category to which an item belongs shapes the organization of these distributed representations.
High-resolution fMRI of Content-sensitive Subsequent Memory Responses in Human Medial Temporal Lobe
TLDR
The present data suggest a gradient of content sensitivity from posterior (parahippocampal) to anterior (perirhinal) MTL cortex, with MTL cortical regions differentially contributing to successful encoding based on event content.
Differences in Mnemonic Processing by Neurons in the Human Hippocampus and Parahippocampal Regions
TLDR
The results suggest that inhibition is a mechanism used by cells in the human hippocampus to support sparse coding in mnemonic processing and provide further evidence for the division of labor in the medial-temporal lobe with respect to declarative memory processes.
...
...

References

SHOWING 1-10 OF 29 REFERENCES
The medial temporal lobe.
TLDR
This analysis draws on studies of human memory impairment and animal models of memory impairment, as well as neurophysiological and neuroimaging data, to show that this system is principally concerned with memory and operates with neocortex to establish and maintain long-term memory.
Anterior Medial Temporal Lobe Activation during Attempted Retrieval of Encoded Visuospatial Scenes: An Event-Related fMRI Study
TLDR
This study uses event-related fMRI to study whether the cognitive process of retrieval of visuospatial scenes, tested with the use of a recognition paradigm, also activates the medial temporal lobe (MTL), and concludes that the left posterior parahippocampal gyrus responds during encoding, while on the other hand the left anterior parahipper gyrus and the right anterior hippocampus were more strongly involved in retrieval.
FMRI activity in the medial temporal lobe during recognition memory as a function of study‐test interval
The phenomenon of temporally graded retrograde amnesia (loss of information acquired before the onset of amnesia) suggests that the hippocampus, and possibly other medial temporal lobe (MTL)
Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys
TLDR
The present results demonstrate not only that damage limited to the rhinal cortex is sufficient to produce a severe loss in visual recognition, but also that such damage leads to a far greater loss than damage to any other single structure in the medial part of the temporal lobe.
The human perirhinal cortex and recognition memory
  • Elizabeth A. Buffalo, Paul J. Reber, Larry R. Squire
  • Biology, Psychology
    Hippocampus
  • 1998
TLDR
The findings suggest that the perirhinal cortex is not important for visual perception or immediate memory, and resemble the findings for other medial temporal lobe structures, including the hippocampus.
The hippocampal formation participates in novel picture encoding: evidence from functional magnetic resonance imaging.
  • C. Stern, S. Corkin, B. Rosen
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1996
TLDR
To the knowledge, this experiment is the first fMRI study to show robust signal changes in the human hippocampal region and provides evidence that the encoding of novel, complex pictures depends upon an interaction between ventral cortical regions, specialized for object vision, and the hippocampal formation and parahippocampal gyrus, specialty for long-term memory.
Real-time tracking of memory formation in the human rhinal cortex and hippocampus.
TLDR
It is suggested that declarative memory formation is dissociable into subprocesses and sequentially organized within the MTL, as well as within the rhinal cortex and the hippocampus.
Two functional components of the hippocampal memory system
TLDR
It is proposed that neocortical association areas maintain shortterm memories for specific items and events prior to hippocampal processing as well as providing the final repositories of long-term memory.
Novelty and familiarity activations in PET studies of memory encoding and retrieval.
TLDR
A 'novelty/encoding hypothesis': novelty assessment represents an early stage of long-term memory encoding and elaborate, meaning-based encoding processes operate on the incoming information to the extent of its novelty, and therefore the probability ofLong-term storage of information varies directly with the novelty of the information.
Dissociable Human Perirhinal, Hippocampal, and Parahippocampal Roles during Verbal Encoding
TLDR
Functional magnetic resonance imaging scanning parameters are adapted to maximize sensitivity to medial temporal lobe activity to demonstrate that left perirhinal and hippocampal responses during word list encoding are greater for subsequently recalled than forgotten words.
...
...