A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

@article{Chan2020AFC,
  title={A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster},
  author={Jasper Fuk-Woo Chan and Shuofeng Yuan and Kin-Hang Kok and Kelvin Kai-Wang To and Hin Chu and Jin Yang and Fanfan Xing and Jieling Liu and Cyril C. Y. Yip and Rosana Wing-Shan Poon and Hoi‐wah Tsoi and Simon Kam-Fai Lo and Kwok-Hung Chan and Vincent Kwok-Man Poon and Wan-Mui Chan and Jonathan Daniel Ip and Jian-Piao Cai and Vincent Chi‐Chung Cheng and Honglin Chen and Christopher K. M. Hui and Kwok Yung Yuen},
  journal={Lancet (London, England)},
  year={2020},
  volume={395},
  pages={514 - 523}
}
Summary Background An ongoing outbreak of pneumonia associated with a novel coronavirus was reported in Wuhan city, Hubei province, China. Affected patients were geographically linked with a local wet market as a potential source. No data on person-to-person or nosocomial transmission have been published to date. Methods In this study, we report the epidemiological, clinical, laboratory, radiological, and microbiological findings of five patients in a family cluster who presented… Expand

Paper Mentions

Interventional Clinical Trial
The aim of this study is to evaluate the safety and efficacy of autologous adipose-derived mesenchymal cells for treating confirmed or suspected patients with SARS-CoV-2 and… Expand
ConditionsCovid-19 Pneumonia, Cyotokine Storm
InterventionBiological
Interventional Clinical Trial
Most patients undergoing a cardiovascular procedure need an ICU-bed during the hospitalization and therefore it is possible that for the unforeseen future, because of the Covid… Expand
ConditionsCardiovascular Diseases, Cardiovascular Risk Factor
InterventionOther
Interventional Clinical Trial
Background: The rapid spread and high infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) makes identifying an effective prophylaxis agent highly important… Expand
ConditionsCoronavirus Disease 2019 (COVID-19), Post-Exposure Prophylaxis
InterventionDrug
Observational Clinical Trial
In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide. Indeed, SARI had a relevant role… Expand
ConditionsARDS, Human, Cardiogenic Shock, COVID, (+4 more)
A Familial Cluster of Infection Associated With the 2019 Novel Coronavirus Indicating Possible Person-to-Person Transmission During the Incubation Period
TLDR
The epidemiological evidence has shown possible transmission of 2019 novel coronavirus during the incubation period, including an 88-year-old man with limited mobility who was exposed only to asymptomatic family members whose symptoms developed later. Expand
Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series
TLDR
As of early February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in Zhejiang province are relatively mild. Expand
Epidemiologic and Clinical Characteristics of 26 Cases of COVID-19 Arising from Patient-to-Patient Transmission in Liaocheng, China
TLDR
Early clinical features of 26 patients with confirmed COVID-19 who were admitted to Liaocheng Infectious Disease Hospital in Shandong Province are reported, suggesting active viral transmission in a location frequented by a large number of people. Expand
Familial cluster of COVID-19 infection from an asymptomatic
TLDR
A familial cluster case of five patients infected with COVID-19 from an asymptomatic confirmed case in Beijing, where just the index patient had been to Wuhan, who had no symptoms before his family members started to get sick one after another. Expand
Investigation of One Familial Cluster of COVID-19 in Taiwan: Differentiation of Genetic Variation Among Isolates and Implications for Epidemiological Investigation and Surveillance by Genomic Assay
TLDR
Phylogenetic tree analysis revealed that these sequences came from Italy, not China, indicating that no major strain has been circulating in Taiwan and several novel mutations were observed in the asymptomatic patient, such as nsp2, nsp12, and nsp14. Expand
Clinical Features of Patients Infected with the 2019 Novel Coronavirus (COVID-19) in Shanghai, China
TLDR
In this single centre cohort of COVID-19 patients, the most common symptom was fever, and the mostCommon laboratory abnormality was decreased blood T cell counts, which were the risk factors most associated with severity of disease. Expand
The epidemiological characteristics of cluster transmission of coronavirus disease 2019 (COVID-19): a multi-center study in Jiangsu Province.
TLDR
It is concluded that asymPTomatic carriers are mainly screened out of clusters and the patients infected by asymptomatic carriers present with milder symptoms than those infected by symptomatic patients, which indicated that the SARS-CoV-2 shares decreased virulence among asymaptomatic carriers. Expand
Molecular epidemiology of SARS-CoV-2 clusters caused by asymptomatic cases in Anhui Province, China
TLDR
This study investigated the origin and transmission route of SARS-CoV-2 in Anhui’s two clusters, analyzed the role and infectiousness of asymptomatic patients in disease transmission, and characterized the complete spike gene sequences in the AnhUI strains. Expand
Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster
TLDR
It is indicated that COVID-19 can be transmitted by asymptomatic carriers during the incubation period. Expand
Person to person transmission of pneumonia associated with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a familial cluster analysis in North Central Nigeria
TLDR
The epidemiological evidence from the study on familial cluster analysis reveals possible transmission of Novel SARS-CoV-2 during the incubation period, and underscores the importance of probing contact history of potentially infected individuals, for prompt identification to preventing further spread. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 40 REFERENCES
Clinical characteristics of 16 patients with COVID-19 infection outside of Wuhan, China: a retrospective, single-center study.
TLDR
The clinical characteristics of hospitalized patients with confirmed COVID-19 infection in Shaoxing city are described to provide an insight into the treatment of CO VID-19 across China and elsewhere, and psychological counseling cannot be ignored. Expand
Coronavirus as a possible cause of severe acute respiratory syndrome
TLDR
Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression. Expand
A Patient with Asymptomatic Severe Acute Respiratory Syndrome (SARS) and Antigenemia from the 2003–2004 Community Outbreak of SARS in Guangzhou, China
  • X. Che, B. Di, +9 authors K. Yuen
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2006
TLDR
The asymptomatic case patient and the second index case patient with SARS in the 2003–2004 outbreak both worked in the same restaurant, where they served palm civets, which were found to carry SARS-associated coronaviruses, which may be a critical stage for virus evolution and disease prevention. Expand
Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1, from Patients with Pneumonia
TLDR
The data support the existence of a novel group 2 coronavirus associated with pneumonia in humans, CoV-HKU1, from a 71-year-old man with pneumonia who had just returned from Shenzhen, China. Expand
Clinical features of severe patients infected with 2019 novel coronavirus: a systematic review and meta-analysis.
TLDR
Severe patients with COVID-19 had more risk of clinical characteristics and multiple system organ complications and even received more main interventions, severe patients had higher risk of mortality. Expand
High prevalence of four novel astrovirus genotype species identified from rodents in China.
TLDR
Phylogenetic analysis of the ORF1b region, which encodes the RdRp, showed that there were four distinct clusters (clusters A, B, C and D), and cluster D was most closely related to the rodent astrovirus previously identified in Hong Kong. Expand
Nosocomial infections among patients with COVID-19, SARS and MERS: a rapid review and meta-analysis.
TLDR
The proportion of nosocomial infection in patients with COVID-19 was 44% in the early outbreak, and nurses and doctors were the most affected among the infected medical staff. Expand
Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats
TLDR
Using pathogenic tests, it is found that the SARS-CoV virus can reproduce and cause disease in suckling rats, and further studies showed that the virus-like particles can be observed in the brains of sucking rats by electron microscopy. Expand
Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease
TLDR
Developing an effective camel MERS-CoV vaccine and implementing appropriate infection control measures may control the continuing epidemic. Expand
Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study
TLDR
The consistent clinical progression, shifting radiological infiltrates, and an inverted V viral-load profile suggest that worsening in week 2 is unrelated to uncontrolled viral replication but may be related to immunopathological damage. Expand
...
1
2
3
4
...