A familial case of renal cell carcinoma and a t(2;3) chromosome translocation.

  title={A familial case of renal cell carcinoma and a t(2;3) chromosome translocation.},
  author={Martijn Koolen and A P van der Meyden and Dani{\"e}lle Bodmer and Marc J. Eleveld and E van der Looij and Han G. Brunner and Arie Smits and Else van den Berg and Dominique F. C. M. Smeets and A D Geurts van Kessel},
  journal={Kidney international},
  volume={53 2},
Cytogenetic analysis was performed on peripheral blood lymphocytes of members of a family with inherited renal cell cancer. Four family members in three generations developed multiple/bilateral renal cell carcinomas of the clear cell type. In one additional case a bladder carcinoma was diagnosed. In two of the renal cell carcinoma patients a constitutional t(2;3)(q35;q21) was encountered, whereas in the two other (deceased) patients the presence of this translocation could be deduced. Also, the… CONTINUE READING


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