A familial 46 XY gonadal dysgenesis and high incidence of embryonic gonadal tumors

  title={A familial 46 XY gonadal dysgenesis and high incidence of embryonic gonadal tumors},
  author={Zheng Eh and Weili Liu},
  journal={Chinese Journal of Cancer Research},
The Swyer’s syndrome, 46XY gonadal dysgenesis (46XYGD) or XY female, belongs to the category of sexual abnomality. The syndrome is characterized by a female phenotype with streak gonads, 46XY karyotype and complicated by frequent develop of gonadal tumors. A congregated familial 46XYGD was analyzed. We have examined the whole family from many aspects and have followed the affected members more than 10 years. In present case, all eight siblings phenotypically were girls; the two eldest members… Expand


Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads.
  • D. Page
  • Biology, Medicine
  • Development
  • 1987
Y-DNA hybridization analysis of individuals with gonadoblastoma and partial deletions of the Y chromosome should be of use in testing this proposal, as studies suggest that GBY maps to the region that includes deletion intervals 4B to 7, i.e. it is located near the centromere or on the long arm of the Ys. Expand
Gonadoblastoma. A review of 74 cases
The gonadoblastoma may be regarded as an in‐situ cancer from which germinomas and occasionally other types of invasive germ‐cell tumor can develop. Expand
Neoplasia arising in dysgenetic gonads.
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A fate map of larval organs of Drosophila and preblastoderm determination.
The construction of embryonic fate maps in Drosophila that locate the foci at which genes exert their primary effects has been extended successfully to internal organs involved in behavioural characters and good agreement between the location of foci of behavioural characters obtained by the genetic method and by direct embryological inferences stresses the reliability of this mapping procedure. Expand
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF. Expand