A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation.

@article{Monteleone2004AFO,
  title={A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation.},
  author={Giovanni Monteleone and Jelena Mann and Ivan Monteleone and Piero Vavassori and Ronald Bremner and Massimo Fantini and Giovanna Del Vecchio Blanco and Roberto Tersigni and Luciano Alessandroni and Derek Mann and Francesco Pallone and Thomas Macdonald},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 6},
  pages={3925-32}
}
Immunologically mediated tissue damage in the gut is associated with increased production of proinflammatory cytokines, which activate the transcription factor NF-kappaB in a variety of different cell types. The mechanisms/factors that negatively regulate NF-kappaB in the human gut and the pathways leading to the sustained NF-kappaB activation in gut inflammation remain to be identified. Pretreatment of normal human intestinal lamina propria mononuclear cells (LPMC) with transforming growth… CONTINUE READING