A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington’s disease in mice

@inproceedings{Acua2013AFI,
  title={A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington’s disease in mice},
  author={An{\'i}bal Ignacio Acu{\~n}a and Magdalena Esparza and Carlos Kramm and Felipe Andr{\'e}s Beltr{\'a}n and Alejandra V. Parra and Carlos Cepeda and Carlos A. Toro and Ren{\'e} Luis Vidal and Claudio Hetz and Ilona I. Concha and Sebasti{\'a}n Brauchi and Michael S Levine and Maite A Castro},
  booktitle={Nature communications},
  year={2013}
}
Huntington's disease has been associated with a failure in energy metabolism and oxidative damage. Ascorbic acid is a powerful antioxidant highly concentrated in the brain where it acts as a messenger, modulating neuronal metabolism. Using an electrophysiological approach in R6/2 HD slices, we observe an abnormal ascorbic acid flux from astrocytes to neurons, which is responsible for alterations in neuronal metabolic substrate preferences. Here using striatal neurons derived from knock-in mice… CONTINUE READING
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