A facile solution phase combinatorial synthesis of tetrasubstituted pyridines using the Bohlmann-Rahtz heteroannulation reaction.

@article{Bagley2003AFS,
  title={A facile solution phase combinatorial synthesis of tetrasubstituted pyridines using the Bohlmann-Rahtz heteroannulation reaction.},
  author={Mark C. Bagley and James W. Dale and Maren Ohnesorge and Xin Xiong and Justin Bower},
  journal={Journal of combinatorial chemistry},
  year={2003},
  volume={5 1},
  pages={41-4}
}
The solution phase combinatorial Bohlmann-Rahtz reaction gives highly functionalized pyridine libraries from enamino esters and alkynones in a single synthetic step. Good product ratios and library purities were obtained in reactions catalyzed by zinc(II) bromide, the acid-catalyzed heteroannulation procedure offering considerable improvements over traditional methodology.