A facile one-step synthesis of cysteinyldopas using mushroom tyrosinase

Abstract

A convenient one-step procedure, based upon the tyrosinase co-oxidation of dopa and cysteine, is reported for the synthesis of 5-S-cysteinyldopa (I) in 74% yield. Secondary products of the reaction turned out to be 2-S-cysteinyldopa (II, 14%), 2,5-S, S-dicysteinyldopa (IV, 5%), and the hitherto unknown 6-S-cysteinyldopa (III, ∼1%).

DOI: 10.1007/BF01946005
0100200'80'83'87'91'95'99'03'07'11'15
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@article{Ito1977AFO, title={A facile one-step synthesis of cysteinyldopas using mushroom tyrosinase}, author={Suguru Ito and Giuseppe Prota}, journal={Experientia}, year={1977}, volume={33}, pages={1118-1119} }