A facile microdialysis interface for on-line desalting and identification of proteins by nano-electrospray ionization mass spectrometry.

The adverse effect of salts, especially inorganic salts, on electrospray ionization mass spectrometry (ESI-MS) is one of the most serious obstacles that might limit its application. Among the numerous desalting approaches, the microdialysis technique is favorable for large molecules, such as proteins. In this work, employing a hollow fiber membrane of… CONTINUE READING