A facile method to screen inhibitors of protein-protein interactions including MDM2-p53 displayed on T7 phage.

Abstract

Protein-protein interactions are essential in many biological processes including cell cycle and apoptosis. It is currently of great medical interest to inhibit specific protein-protein interactions in order to treat a variety of disease states. Here, we describe a facile multiwell plate assay method using T7 phage display to screen for candidate inhibitors… (More)
DOI: 10.1016/j.bcp.2008.01.020

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