A facile approach for dual-responsive prodrug nanogels based on dendritic polyglycerols with minimal leaching.

@article{Zhang2014AFA,
  title={A facile approach for dual-responsive prodrug nanogels based on dendritic polyglycerols with minimal leaching.},
  author={Xuejiao Zhang and Katharina Achazi and Dirk Steinhilber and Felix Kratz and Jens Dernedde and Rainer Haag},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={174},
  pages={209-16}
}
A novel pH and redox dual-responsive prodrug nanogel was prepared by an inverse nanoprecipitation method, which is mild and surfactant free, and based on a thiol-disulfide exchange reaction and thiol-Michael addition reaction. Highly biocompatible hyperbranched polyglycerol (hPG) was cross-linked with disulfide bonds, to obtain biodegradable nanogels, which could be degraded under intracellular reductive conditions. Doxorubicin (DOX) was conjugated to the biodegradable nanogel matrix via an… CONTINUE READING