A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis.

  title={A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis.},
  author={Y Q Cheng and Jonathan D. Walton},
  journal={The Journal of biological chemistry},
  volume={275 7},
The cyclic tetrapeptide HC-toxin is an essential virulence determinant for the plant pathogenic fungus Cochliobolus carbonum and an inhibitor of histone deacetylase. The major form of HC-toxin contains the D-isomers of Ala and Pro. The non-ribosomal peptide synthetase that synthesizes HC-toxin has only one epimerizing domain for conversion of L-Pro to D-Pro; the source of D-Ala has remained unknown. Here we present the cloning and characterization of a new gene involved in HC-toxin biosynthesis… CONTINUE READING


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