A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis.

@article{Cheng2000AEA,
  title={A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis.},
  author={Y Q Cheng and Jonathan D. Walton},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 7},
  pages={4906-11}
}
The cyclic tetrapeptide HC-toxin is an essential virulence determinant for the plant pathogenic fungus Cochliobolus carbonum and an inhibitor of histone deacetylase. The major form of HC-toxin contains the D-isomers of Ala and Pro. The non-ribosomal peptide synthetase that synthesizes HC-toxin has only one epimerizing domain for conversion of L-Pro to D-Pro; the source of D-Ala has remained unknown. Here we present the cloning and characterization of a new gene involved in HC-toxin biosynthesis… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-3 of 3 references

HC-toxin analysis of the toxG null mutant. Following chloroform extraction of the culture filtrates, HC-toxin was chromatographed on silica gel TLC and detected using an epoxide-specific reagent

  • V. De Crécy-Lagard, P. Marlière, W. Saurin
  • C. R. Acad. Sci
  • 1995

Molecular Cloning: A Laboratory Manual, 2nd ed

  • J. Sambrook, E. F. Fritsch, T. Maniatis
  • Cold Spring Harbor Laboratory,
  • 1989

Host-selective Toxins from Helminthosporium carbonum: Purification, Chemistry, Biological Activities, and Effect on Chlorophyll Synthesis in Maize, Ph.D

  • J. B. Rasmussen
  • 1987

Similar Papers

Loading similar papers…