A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells.

@article{Krueger2003ADC,
  title={A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells.},
  author={Eugene W Krueger and James D. Orth and Hong Long Cao and Mark A McNiven},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 3},
  pages={
          1085-96
        }
}
The mechanisms by which mammalian cells remodel the actin cytoskeleton in response to motogenic stimuli are complex and a topic of intense study. Dynamin 2 (Dyn2) is a large GTPase that interacts directly with several actin binding proteins, including cortactin. In this study, we demonstrate that Dyn2 and cortactin function to mediate dynamic remodeling of the actin cytoskeleton in response to stimulation with the motogenic growth factor platelet-derived growth factor. On stimulation, Dyn2 and… CONTINUE READING

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