A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells.

  title={A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells.},
  author={E. Krueger and J. D. Orth and H. Cao and M. McNiven},
  journal={Molecular biology of the cell},
  volume={14 3},
  • E. Krueger, J. D. Orth, +1 author M. McNiven
  • Published 2003
  • Biology, Medicine
  • Molecular biology of the cell
  • The mechanisms by which mammalian cells remodel the actin cytoskeleton in response to motogenic stimuli are complex and a topic of intense study. Dynamin 2 (Dyn2) is a large GTPase that interacts directly with several actin binding proteins, including cortactin. In this study, we demonstrate that Dyn2 and cortactin function to mediate dynamic remodeling of the actin cytoskeleton in response to stimulation with the motogenic growth factor platelet-derived growth factor. On stimulation, Dyn2 and… CONTINUE READING
    204 Citations

    Figures and Topics from this paper

    Dynamin2 GTPase and Cortactin Remodel Actin Filaments*
    • 104
    • PDF
    Dynamin2 Organizes Lamellipodial Actin Networks to Orchestrate Lamellar Actomyosin
    • 10
    • PDF
    Dynamin 2 interacts with α-actinin 4 to drive tumor cell invasion
    • 3
    A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines
    • 55
    • PDF
    Essential Function of Dynamin in the Invasive Properties and Actin Architecture of v-Src Induced Podosomes/Invadosomes
    • 27
    • PDF
    Abl2 is recruited to ventral actin waves through cytoskeletal interactions to promote lamellipodium extension
    • 4
    • Highly Influenced


    Dynamin2 and Cortactin Regulate Actin Assembly and Filament Organization
    • 184
    Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1.
    • 193
    • PDF
    Cortactin Localization to Sites of Actin Assembly in Lamellipodia Requires Interactions with F-Actin and the Arp2/3 Complex
    • 396
    • PDF
    The large GTPase dynamin regulates actin comet formation and movement in living cells
    • 224
    • PDF
    Down-regulation of the Filamentous Actin Cross-linking Activity of Cortactin by Src-mediated Tyrosine Phosphorylation*
    • 257
    • PDF
    The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton.
    • 182
    • PDF