A dynamical model of oncotripsy by mechanical cell fatigue: selective cancer cell ablation by low-intensity pulsed ultrasound

@article{Schibber2020ADM,
  title={A dynamical model of oncotripsy by mechanical cell fatigue: selective cancer cell ablation by low-intensity pulsed ultrasound},
  author={Erika F. Schibber and David Reza Mittelstein and Morteza Gharib and Mikhail G. Shapiro and Patrick Pak-Ching Lee and Michael Ortiz},
  journal={Proceedings of the Royal Society A},
  year={2020},
  volume={476}
}
The method of oncotripsy, first proposed in Heyden & Ortiz (Heyden & Ortiz 2016 J. Mech. Phys. Solids 92, 164–175 (doi:10.1016/j.jmps.2016.04.016)), exploits aberrations in the material properties and morphology of cancerous cells in order to ablate them selectively by means of tuned low-intensity pulsed ultrasound. We propose the dynamical model of oncotripsy that follows as an application of cell dynamics, statistical mechanical theory of network elasticity and ‘birth–death’ kinetics to… 
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