A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration.

@article{Mercer2013ADS,
  title={A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration.},
  author={Sarah E. Mercer and Shannon Odelberg and Hans-Georg Simon},
  journal={Developmental biology},
  year={2013},
  volume={382 2},
  pages={
          457-69
        }
}
Unlike humans, certain adult vertebrates such as newts and zebrafish possess extraordinary abilities to functionally regenerate lost appendages and injured organs, including cardiac muscle. Here, we present new evidence that a remodeled extracellular matrix (ECM) directs cell activities essential for cardiac muscle regeneration. Comprehensive mining of DNA microarrays and Gene Ontology term enrichment analyses for regenerating newt and zebrafish hearts revealed that distinct ECM components and… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 48 CITATIONS

Characterisation of the ADAMTS family in Xenopus development

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Dynamic remodeling of the extra cellular matrix during zebrafish fin regeneration.

  • Gene expression patterns : GEP
  • 2015
VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Beyond the Mammalian Heart: Fish and Amphibians as a Model for Cardiac Repair and Regeneration

  • Journal of developmental biology
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Differential reparative phenotypes between zebrafish and medaka after cardiac injury.

  • Developmental dynamics : an official publication of the American Association of Anatomists
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Gene profile of zebrafish fin regeneration offers clues to kinetics, organization and biomechanics of basement membrane.

  • Matrix biology : journal of the International Society for Matrix Biology
  • 2019
VIEW 2 EXCERPTS
CITES RESULTS

References

Publications referenced by this paper.
SHOWING 1-10 OF 76 REFERENCES

Biochemical and mechanical environment cooperatively regulate skeletal muscle regeneration.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2012
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL