A dynamic regulation of GDNF-family receptors correlates with a specific trophic dependency of cranial motor neuron subpopulations during development.

@article{Mikaels2000ADR,
  title={A dynamic regulation of GDNF-family receptors correlates with a specific trophic dependency of cranial motor neuron subpopulations during development.},
  author={A Mikaels and J. Livet and Heiner Westphal and Odile de Lapeyri{\`e}re and Patrik Ernfors},
  journal={The European journal of neuroscience},
  year={2000},
  volume={12 2},
  pages={446-56}
}
Glial cell line-derived neurotrophic factor (GDNF) family ligands promote the survival of developing motor neurons in vivo and in vitro. However, not all neurons survive with any single ligand in culture and GDNF null mutant mice display only a partial motor neuron loss. An interesting possibility is that subpopulations of motor neurons based on their function and/or their myotopic organization require distinct members of GDNF family ligands. Because responsiveness to the different ligands… CONTINUE READING

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