A dynamic model of the type-2 inositol trisphosphate receptor.

Abstract

The dynamic properties of the inositol (1,4,5)-trisphosphate (IP(3)) receptor are crucial for the control of intracellular Ca(2+), including the generation of Ca(2+) oscillations and waves. However, many models of this receptor do not agree with recent experimental data on the dynamic responses of the receptor. We construct a model of the IP(3) receptor and… (More)

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@article{Sneyd2002ADM, title={A dynamic model of the type-2 inositol trisphosphate receptor.}, author={James Sneyd and Jean-François Dufour}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2002}, volume={99 4}, pages={2398-403} }