A dynamic model of excitation-contraction coupling during acidosis in cardiac ventricular myocytes.

@article{Crampin2006ADM,
  title={A dynamic model of excitation-contraction coupling during acidosis in cardiac ventricular myocytes.},
  author={Edmund J. Crampin and Nicolas Peter Smith},
  journal={Biophysical journal},
  year={2006},
  volume={90 9},
  pages={3074-90}
}
Acidosis in cardiac myocytes is a major factor in the reduced inotropy that occurs in the ischemic heart. During acidosis, diastolic calcium concentration and the amplitude of the calcium transient increase, while the strength of contraction decreases. This has been attributed to the inhibition by protons of calcium uptake and release by the sarcoplasmic reticulum, to a rise of intracellular sodium caused by activation of sodium-hydrogen exchange, decreased calcium binding affinity to Troponin… CONTINUE READING

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