A dynamic mode of mitotic bookmarking by transcription factors

  title={A dynamic mode of mitotic bookmarking by transcription factors},
  author={Sheila S Teves and Luye An and Anders S Hansen and Liangqi Xie and Xavier Darzacq and Robert Tjian},
During mitosis, transcription is shut off, chromatin condenses, and most transcription factors (TFs) are reported to be excluded from chromosomes. How do daughter cells re-establish the original transcription program? Recent discoveries that a select set of TFs remain bound on mitotic chromosomes suggest a potential mechanism for maintaining transcriptional programs through the cell cycle termed mitotic bookmarking. Here we report instead that many TFs remain associated with chromosomes in… CONTINUE READING
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