A dynamic membrane reactor with immobilized α-chymotrypsin for continuous kyotorphin synthesis in organic media

Abstract

α-Chymotrypsin was covalently attached to an α-alumina ultrafiltration membrane coated with an inert protein. This derivative was used as catalyst for the continuous kinetically controlled synthesis of kyotorphin in both membrane and packed bed reactors, using aqueous (water/dimethyl sulfoxide, 60:40, v/v) and nearly-dry (hexane/ethanol/water, 57:40:3, by… (More)
DOI: 10.1023/A:1005690604799

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