A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes.

  title={A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes.},
  author={Terje Sagvolden and Espen Borg{\aa} Johansen and Heidi Aase and Vivienne Ann Russell},
  journal={The Behavioral and brain sciences},
  volume={28 3},
          397-419; discussion 419-68
Attention-deficit/hyperactivity disorder (ADHD) is currently defined as a cognitive/behavioral developmental disorder where all clinical criteria are behavioral. Inattentiveness, overactivity, and impulsiveness are presently regarded as the main clinical symptoms. The dynamic developmental behavioral theory is based on the hypothesis that altered dopaminergic function plays a pivotal role by failing to modulate nondopaminergic (primarily glutamate and GABA) signal transmission appropriately. A… 

Brain functional domains inform therapeutic interventions in attention-deficit/hyperactivity disorder and pediatric bipolar disorder

The reward-related mechanisms underlying the interactions between executive function, behavior regulation and impulsivity in PBD and ADHD may be differentially compromised, and in accordance differently shape the clinical symptoms of impulsivity and goal-directed behavior.

An integrative theory of attention-deficit/ hyperactivity disorder based on the cognitive and affective neurosciences

Attention-deficit/hyperactivity disorder (ADHD) is a behavioral syndrome that arises in early childhood, often co-occurs with conduct disorder and leads, developmentally, to antisocial behavior and

Neurobiology of animal models of attention-deficit hyperactivity disorder

  • V. Russell
  • Biology, Psychology
    Journal of Neuroscience Methods
  • 2007

Frontal Dysfunctions of Impulse Control – A Systematic Review in Borderline Personality Disorder and Attention-Deficit/Hyperactivity Disorder

Overall, patients with BPD exhibited prefrontal dysfunctions across impulse control components rather in orbitofrontal, dorsomedial, and dorsolateral prefrontal regions, whereas patients with ADHD displayed disturbed activity mainly in ventrolateral and medial prefrontal regions.

Behavioral and Brain Functions

Background: The behaviour of children with Attention-Deficit/Hyperactivity Disorder is characterized by low predictability of responding. Low behavioural predictability is one way of operationalizing

Poor response inhibition: At the nexus between substance abuse and attention deficit/hyperactivity disorder

A lifetime of attention-deficit/hyperactivity disorder: diagnostic challenges, treatment and neurobiological mechanisms

Converging evidence from clinical and genetic studies are presented arguing for a remarkable perseverance of ADHD-related symptomatology, taking into account the disorder’s variable and changing phenotype moderated by a high rate of comorbidity throughout the lifecycle.



Attention deficit/hyperactivity disorder--from brain dysfunctions to behaviour.

The combined insights of the articles presented here suggest that there is no brain damage in ADHD, but hypo-efficient dopamine systems which give rise to neurochemical imbalances which cause behavioural problems: deficits in sustained attention, overactivity and impulsiveness.

Developmental neuropsychopathology of attention deficit and impulsiveness

  • E. Taylor
  • Psychology
    Development and Psychopathology
  • 1999
This formulation emphasizes the need for several types of research: the mapping of biological findings onto different components of disorder, the combination of genetically informative designs with direct measurement of relevant aspects of the environment, and the use of longitudinal studies to examine predictive and mediating factors separately for different aspects of outcome.

Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD.

  • R. Barkley
  • Psychology, Biology
    Psychological bulletin
  • 1997
A theoretical model that links inhibition to 4 executive neuropsychological functions that appear to depend on it for their effective execution is constructed and finds it to be strongest for deficits in behavioral inhibition, working memory, regulation of motivation, and motor control in those with ADHD.

Current concepts on the neurobiology of Attention-Deficit/Hyperactivity Disorder

Although not entirely sufficient, changes in dopaminergic and noradrenergic function appear necessary for the clinical efficacy of pharmacological treatments for ADHD, providing support for the hypothesis that alteration of monoaminergic transmission in critical brain regions may be the basis for therapeutic action in ADHD.

Temperament and Attention Deficit Hyperactivity Disorder: The Development of a Multiple Pathway Model

  • J. NiggH. GoldsmithJennifer Sachek
  • Psychology
    Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
  • 2004
It is hypothesized that, whereas regulation problems may occur in most children with ADHD, a subgroup also may be characterized by positive approach problems and another subgroup by negative approach problems, and a theorized multiple process developmental model outlining alternate pathways to ADHD is proposed.