A dynamic, mitotic-like mechanism for bacterial chromosome segregation.

  title={A dynamic, mitotic-like mechanism for bacterial chromosome segregation.},
  author={Michael A. Fogel and Matthew K Waldor},
  journal={Genes & development},
  volume={20 23},
The mechanisms that mediate chromosome segregation in bacteria are poorly understood. Despite evidence of dynamic movement of chromosome regions, to date, mitotic-like mechanisms that act on the bacterial chromosome have not been demonstrated. Here we provide evidence that the Vibrio cholerae ParAI and ParBI proteins are components of an apparatus that pulls the origin region of the large V. cholerae chromosome to the cell pole and anchors it there. ParBI interacts with a conserved origin… CONTINUE READING
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