A dyad oct-binding sequence functions as a maintenance sequence for the unmethylated state within the H19/Igf2-imprinted control region.

@article{Hori2002ADO,
  title={A dyad oct-binding sequence functions as a maintenance sequence for the unmethylated state within the H19/Igf2-imprinted control region.},
  author={Naohiro Hori and Hiroshi Nakano and Toshiyuki Takeuchi and H. Ogata H. Kato and Sayuri Hamaguchi and Mitsuo Oshimura and Kenzo Sato},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 31},
  pages={27960-7}
}
DNA methylation of an imprinted control region (ICR) directs the allele-specific and reciprocal expression of the mouse H19 and the insulin-like growth factor 2 (Igf2) genes, mediated by controlling enhancer access. The ICR shows enhancer blocking activity through CTCF binding to an unmethylated sequence. The unmethylated state of the maternal ICR is maintained throughout development after establishment in the germ line; however, little is known of the molecular mechanisms that regulate DNA… CONTINUE READING

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