A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age.

@article{Berryman2014ADM,
  title={A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age.},
  author={Darlene E. Berryman and Ellen R. Lubbers and Vishakha Magon and Edward O. List and John J. Kopchick},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2014},
  volume={69 2},
  pages={131-41}
}
Reduced growth hormone (GH) action is associated with extended longevity in many vertebrate species. GH receptor (GHR) null (GHR(-)(/-)) mice, which have a disruption in the GHR gene, are a well-studied example of mice that are insulin sensitive and long lived yet obese. However, unlike other mouse lines with reduced GH action, GH receptor antagonist (GHA) transgenic mice have reduced GH action yet exhibit a normal, not extended, life span. Understanding why GHA mice do not have extended life… CONTINUE READING
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