A dual upstream open reading frame-based autoregulatory circuit controlling polyamine-responsive translation.

@article{Hanfrey2005ADU,
  title={A dual upstream open reading frame-based autoregulatory circuit controlling polyamine-responsive translation.},
  author={Colin C Hanfrey and Katherine A. Elliott and Marina Franceschetti and Melinda J. Mayer and Crista Illingworth and Anthony J. Michael},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 47},
  pages={39229-37}
}
A novel form of translational regulation is described for the key polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC). Plant AdoMetDC mRNA 5' leaders contain two highly conserved overlapping upstream open reading frames (uORFs): the 5' tiny and 3' small uORFs. We demonstrate that the small uORF-encoded peptide is responsible for constitutively repressing downstream translation of the AdoMetDC proenzyme ORF in the absence of increased polyamine levels. This first example… CONTINUE READING

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