A dual role of p53 in the control of autophagy.

  title={A dual role of p53 in the control of autophagy.},
  author={Ezgi Tasdemir and M. Chiara Maiuri and Eugenia Morselli and Alfredo Criollo and Marcello D'Amelio and Mojgan Djavaheri-Mergny and Francesco Cecconi and Nektarios Tavernarakis and Guido Kroemer},
  volume={4 6},
Genotoxic stress can induce autophagy in a p53-dependent fashion and p53 can transactivate autophagy-inducing genes. We have observed recently that inactivation of p53 by deletion, depletion or inhibition can trigger autophagy. Thus, human and mouse cells subjected to knockout, knockdown or pharmacological inhibition of p53 manifest signs of autophagy such as depletion of p62/SQSTM1, LC3 lipidation, redistribution of GFP-LC3 in cytoplasmic puncta, and accumulation of autophagosomes and… CONTINUE READING
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