A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation.

@article{Kamieniarz2012ADR,
  title={A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation.},
  author={Kinga Kamieniarz and Annalisa Izzo and Miroslav Dundr and Philipp Tropberger and Luka Ozreti{\'c} and Jutta Kirfel and Elisabeth Scheer and Philippe Tropel and Jacek R. Wisniewski and L{\'a}szl{\'o} Tora and St{\'e}phane Viville and Reinhard Mechoulam Raphael Buettner and Robert J. Schneider},
  journal={Genes & development},
  year={2012},
  volume={26 8},
  pages={
          797-802
        }
}
The linker histone H1 is a key player in chromatin organization, yet our understanding of the regulation of H1 functions by post-translational modifications is very limited. We provide here the first functional characterization of H1 acetylation. We show that H1.4K34 acetylation (H1.4K34ac) is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 mobility and recruiting a general transcription factor. H1.4K34ac is… CONTINUE READING

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