A dual role for the Ca2+-requiring proteinase in the degradation of hemoglobin by erythrocyte membrane proteinases.

@article{Pontremoli1984ADR,
  title={A dual role for the Ca2+-requiring proteinase in the degradation of hemoglobin by erythrocyte membrane proteinases.},
  author={Sandro Pontremoli and Edoardo Melloni and Bianca Sparatore and Miqu{\'e}ias Michetti and Bernard Leonard Horecker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 21},
  pages={
          6714-7
        }
}
Binding of hemoglobin chains to erythrocyte membranes is an obligatory step in the conversion of hemoglobin to acid-soluble products by erythrocyte proteinases. This binding requires limited proteolysis of the hemoglobin chains and also modification of the inner surface of the erythrocyte membrane, both of which result from the action of a soluble Ca2+-requiring neutral proteinase. Final digestion of the bound hemoglobin chains in the membrane complex results from the action of intrinsic… CONTINUE READING
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