A dual role for lecithin:cholesterol acyltransferase (EC 2.3.1.43) in lipoprotein oxidation.

Abstract

Lecithin:cholesterol acyltransferase (LCAT) is a key enzyme involved in lipoprotein metabolism. It mediates the transesterification of free cholesterol to cholesteryl ester in an apoprotein A-I-dependent process. We have isolated purified LCAT from human plasma using anion-exchange chromatography and characterized the extracted LCAT in terms of its… (More)

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