A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration

@inproceedings{Wilson2012ADR,
  title={A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration},
  author={Garrick K. Wilson and Claire L. Brimacombe and Ian A Rowe and Gary M. Reynolds and Nicola F. Fletcher and Zania Stamataki and Ricky H Bhogal and Maria L{\'u}cia Garcia Sim{\~o}es and Margaret Ashcroft and Simon C Afford and Ragai R. Mitry and Anil Dhawan and Christopher J. Mee and Stefan G. H{\"u}bscher and Peter Balfe and Jane A McKeating},
  booktitle={Journal of hepatology},
  year={2012}
}
BACKGROUND & AIMS Hepatitis C virus (HCV) causes progressive liver disease and is a major risk factor for the development of hepatocellular carcinoma (HCC). However, the role of infection in HCC pathogenesis is poorly understood. We investigated the effect(s) of HCV infection and viral glycoprotein expression on hepatoma biology to gain insights into the development of HCV associated HCC. METHODS We assessed the effect(s) of HCV and viral glycoprotein expression on hepatoma polarity… CONTINUE READING
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