A dual role for autophagy in a murine model of lung cancer.

  title={A dual role for autophagy in a murine model of lung cancer.},
  author={Shuan Rao and Luigi Tortola and Thomas Perlot and Gerald Wirnsberger and Maria Novatchkova and Roberto Nitsch and Peter Sykacek and Lukas Frank and Daniel Schramek and Vukoslav Komnenovic and Verena Sigl and Karin Aumayr and Gerald Schmauss and Nicole Fellner and Stephan Handschuh and Martin Gloesmann and Pawel Pasierbek and Michaela Schlederer and Guenter Paul Resch and Yuting Ma and Heng Yang and Helmuth Popper and Lukas Kenner and Guido Kroemer and Josef M. Penninger},
  journal={Nature communications},
Autophagy is a mechanism by which starving cells can control their energy requirements and metabolic states, thus facilitating the survival of cells in stressful environments, in particular in the pathogenesis of cancer. Here we report that tissue-specific inactivation of Atg5, essential for the formation of autophagosomes, markedly impairs the progression of KRas(G12D)-driven lung cancer, resulting in a significant survival advantage of tumour-bearing mice. Autophagy-defective lung cancers… CONTINUE READING
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